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IUPHAR ECR review: The cGAS-STING pathway: Novel functions beyond innate immune and emerging therapeutic opportunities

11 Jan 2024

Abstract excerpt

Stimulator of interferon genes (STING) is a crucial innate immune sensor responsible for distinguishing pathogens and cytosolic DNA, mediating innate immune signaling pathways to defend the host. Recent studies have revealed additional regulatory functions of STING beyond its innate immune-related activities, including the regulation of cellular metabolism, DNA repair, cellular senescence, autophagy and various...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 38216006
DOI: 10.1016/j.phrs.2024.107063

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