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cGAS-STING pathway in cancer biotherapy

4 Sept 2020

Abstract excerpt

The activation of the cGAS-STING pathway has tremendous potential to improve anti-tumor immunity by generating type I interferons. In recent decades, we have witnessed that producing dsDNA upon various stimuli is an initiative factor, triggering the cGAS-SING pathway for a defensive host. The understanding of both intracellular cascade reaction and the changes of molecular components gains insight into type I...

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PMID: 32887628
DOI: 10.1186/s12943-020-01247-w

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