Article

Characterization of a Novel Transmembrane Activating STING Agonist using Genetically Humanized Mice

2025-07-18

Abstract excerpt

STING is a pattern recognition receptor that activates type I interferon and proinflammatory responses in addition to unrelated molecular processes following exposure of DNA to the cytosol. Its pharmacologic stimulation enhances vaccine potency and generates effective antitumor responses but clinical trials evaluating STING agonists have not led to approval for human use. STING activation can occur through ligand...

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Literature Corpus work: 3c1faf93-c3f2-5a7d-a196-8c12b735b8ea
DOI: 10.1101/2025.07.14.664814

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