Article

Deep mutational scanning reveals a tight correlation between protein degradation and toxicity of thousands of non-native aspartoacylase protein variants

2023-10-02

Abstract excerpt

When the structural stability of a protein is compromised, the protein may form non-native interactions with other cell proteins and thus becomes a hazard to the cell. To mitigate this danger, destabilized proteins are targeted by the cellular protein quality control (PQC) network, which either corrects the folding defect or targets the protein for degradation. However, the details of how the protein folding and d...

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Literature Corpus work: 73070b3c-813e-515f-b383-3fd35d18060b
DOI: 10.1101/2023.10.02.560410

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