Article

Natively entangled proteins are linked to human disease and pathogenic mutations likely due to a greater misfolding propensity

2026-04-20

Abstract excerpt

A recently discovered class of protein misfolding involving native entanglements could be a widespread mechanism by which loss-of-function diseases arise. Here, we test that hypothesis by examining if there is any statistical association between proteins predisposed to misfold in this way and a database of gene-disease relationships. We find that globular proteins containing non-covalent lasso entanglements (NCLEs...

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Literature Corpus work: c774bd24-c85e-582a-b76b-cb3d472095f3
DOI: 10.64898/2026.04.15.718104

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