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Article

Mismatched and wobble base pairs govern primary microRNA processing by human Microprocessor.

Nature communications - 21 Apr 2020

Li Shaohua, Nguyen Trung Duc, Nguyen Thuy Linh, Nguyen Tuan Anh

Abstract excerpt

MicroRNAs (miRNAs) are small RNAs that regulate gene expression. miRNAs are produced from primary miRNAs (pri-miRNAs), which are cleaved by Microprocessor. Microprocessor, therefore, plays a crucial role in determining the efficiency and precision of miRNA production, and thus the function of the final miRNA product. Here, we conducted high-throughput enzymatic assays to investigate the catalytic mechanism of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32317642
DOI: 10.1038/s41467-020-15674-2
PMCID: PMC7174388

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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