Article

Interpretable network-guided epistasis detection

2020-09-25

Abstract excerpt

Detecting epistatic interactions at the gene level is essential to understanding the biological mechanisms of complex diseases. Unfortunately, genome-wide interaction association studies (GWAIS) involve many statistical challenges that make such detection hard. We propose a multi-step protocol for epistasis detection along the edges of a gene-gene co-function network. Such an approach reduces the number of tests p...

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Literature Corpus work: eaf1697e-7ab7-5980-a4f7-2d0b4865a001
DOI: 10.1101/2020.09.24.310136

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