Article
Network theory for data-driven epistasis networks.
Methods in molecular biology (Clifton, N.J.) - 1 Jan 2015
Lareau Caleb A, McKinney Brett A
Abstract excerpt
One of the challenges of understanding the genetic basis of complex phenotypes is explaining variability not attributable to individual genes. While most existing methods that investigate variant mutations or differential gene expression focus on individual effects, a complex system of gene interactions (epistasis) and pathways is likely needed to explain phenotypic variation. Herein, we examine methods for...
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