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Article

Interpretable network-guided epistasis detection.

GigaScience - 4 Feb 2022

Duroux Diane, Climente-González Héctor, Azencott Chloé-Agathe, Van Steen Kristel

Abstract excerpt

BACKGROUND: Detecting epistatic interactions at the gene level is essential to understanding the biological mechanisms of complex diseases. Unfortunately, genome-wide interaction association studies involve many statistical challenges that make such detection hard. We propose a multi-step protocol for epistasis detection along the edges of a gene-gene co-function network. Such an approach reduces the number of...

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Share to Epistasis, Genetic
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Polymorphism, Single Nucleotide

Share to Quantitative Trait Loci

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Identifiers

PMID: 35134928
DOI: 10.1093/gigascience/giab093
PMCID: PMC8848319

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