Article
Characterizing genetic interactions in human disease association studies using statistical epistasis networks.
BMC bioinformatics - 12 Sept 2011
Hu Ting, Sinnott-Armstrong Nicholas A, Kiralis Jeff W, Andrew Angeline S, Karagas Margaret R, Moore Jason H
Abstract excerpt
BACKGROUND: Epistasis is recognized ubiquitous in the genetic architecture of complex traits such as disease susceptibility. Experimental studies in model organisms have revealed extensive evidence of biological interactions among genes. Meanwhile, statistical and computational studies in human populations have suggested non-additive effects of genetic variation on complex traits. Although these studies form a...
Topics
- Adult
- Aged
- Epistasis, Genetic
- Genotype
- Humans
- Middle Aged
- New Hampshire
- Polymorphism, Single Nucleotide
- Urinary Bladder Neoplasms