Article
RAPID detection of gene-gene interactions in genome-wide association studies.
Bioinformatics (Oxford, England) - 15 Nov 2010
Brinza Dumitru, Schultz Matthew, Tesler Glenn, Bafna Vineet
Abstract excerpt
MOTIVATION: In complex disorders, independently evolving locus pairs might interact to confer disease susceptibility, with only a modest effect at each locus. With genome-wide association studies on large cohorts, testing all pairs for interaction confers a heavy computational burden, and a loss of power due to large Bonferroni-like corrections. Correspondingly, limiting the tests to pairs that show marginal...
Topics
- Databases, Genetic
- Gene Expression
- Genome-Wide Association Study
- Genomics
- Polymorphism, Single Nucleotide
- Software