Article
EPIBLASTER-fast exhaustive two-locus epistasis detection strategy using graphical processing units.
European journal of human genetics : EJHG - 1 Apr 2011
Kam-Thong Tony, Czamara Darina, Tsuda Koji, Borgwardt Karsten, Lewis Cathryn M, Erhardt-Lehmann Angelika, Hemmer Bernhard, Rieckmann Peter, Daake Markus, Weber Frank, Wolf Christiane, Ziegler Andreas, Pütz Benno, Holsboer Florian, Schölkopf Bernhard, Müller-Myhsok Bertram
Abstract excerpt
Detection of epistatic interaction between loci has been postulated to provide a more in-depth understanding of the complex biological and biochemical pathways underlying human diseases. Studying the interaction between two loci is the natural progression following traditional and well-established single locus analysis. However, the added costs and time duration required for the computation involved have thus far...
Topics
- Algorithms
- Case-Control Studies
- Computer Graphics
- Epistasis, Genetic
- Genetic Predisposition to Disease
- Genome-Wide Association Study
- Humans
- Logistic Models
- Polymorphism, Single Nucleotide