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Article

First-Order Correction of Statistical Significance for Screening Two-Way Epistatic Interactions.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2021

Cheng Lu, Zhu Mu

Abstract excerpt

If one uses data to identify the most likely epistatic interaction between two genetic units, and then tests if the identified interaction is associated with a phenotype, the nominal statistical evidence will be inflated. Corrections are available but computationally expensive for genome-wide studies. We provide a first-order correction that can be applied in practice with essentially no additional computational...

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PMID: 33733357
DOI: 10.1007/978-1-0716-0947-7_12

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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