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Article

Using biological networks to search for interacting loci in genome-wide association studies.

European journal of human genetics : EJHG - 1 Oct 2009

Emily Mathieu, Mailund Thomas, Hein Jotun, Schauser Leif, Schierup Mikkel Heide

Abstract excerpt

Genome-wide association studies have identified a large number of single-nucleotide polymorphisms (SNPs) that individually predispose to diseases. However, many genetic risk factors remain unaccounted for. Proteins coded by genes interact in the cell, and it is most likely that certain variants mainly affect the phenotype in combination with other variants, termed epistasis. An exhaustive search for epistatic...

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Identifiers

PMID: 19277065
DOI: 10.1038/ejhg.2009.15
PMCID: PMC2986645

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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