Article

Modulating Neural Excitability in Epilepsy: A Systems-Level Perspective on Cannabinoid–Terpene Signaling

2026-04-20

Abstract excerpt

Epilepsy is increasingly understood as a disorder of neural circuit hyperexcitability arising from disruptions in the balance between excitatory glutamatergic and inhibitory GABAergic signaling. In many forms of epilepsy, recurrent seizures are associated with excessive glutamate release and calcium influx, along with inflammatory signaling, oxidative stress, and maladaptive changes in synaptic transmission. These...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: ad5b18a4-1973-5508-946e-5f201737b3f4
DOI: 10.20944/preprints202604.1340.v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Modulating Neural Excitability in Epilepsy: A Systems-Level Perspective on Cannabinoid–Terpene SignalingDOI 10.20944/preprints202604.1340.v1Read

Endocannabinoid signaling in epilepsySemantic proximity Read

Pathophysiology of epilepsy.Semantic proximity Read

WITHDRAWN: Astaxanthin improved carbamazepine efficacy and mood comorbidities in epileptic rats through GABAergic signaling pathway enhancementSemantic proximity Read

Inhibition of Endocannabinoid Degradation in Astrocytes Reprograms Glial Reactivity and Prevents Seizure SequelaeSemantic proximity Read

Cannabidiol as a new treatment for drug-resistant epilepsy in tuberous sclerosis complex.Semantic proximity Read

Integrative Analysis Revealed Common Genes, Brain Cell-Type and Pathways Between Stiripentol Targets and Risk Genes of Dravet Syndrome and EpilepsySemantic proximity Read

Endocannabinoid signaling in brain diseases: Emerging relevance of glial cellsSemantic proximity Read

Somatic and terminal CB1 receptors are differentially coupled to voltage-gated sodium channels in neocortical neuronsSemantic proximity Read

A Multiscale Structural, Pharmacokinetic–Pharmacodynamic and Systems Pharmacology Framework Exploring a Plausible Interaction Between Cenobamate and Low-Dose Clobazam in Drug-Resistant EpilepsySemantic proximity Read

Endocannabinoids Modulate Olfactory System Development and FunctionSemantic proximity Read

Characterization and Anticonvulsant Effects of a Colombian Cannabis sativa Extract: A Preclinical Study in Murine Models of EpilepsySemantic proximity Read

Cannabidiol in Neurology: Current Insights and Translational PerspectivesSemantic proximity Read