Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

High concordance between hippocampal transcriptome of the mouse intra‐amygdala kainic acid model and human temporal lobe epilepsy

18 Oct 2020

Abstract excerpt

OBJECTIVE: Pharmacoresistance and the lack of disease-modifying actions of current antiseizure drugs persist as major challenges in the treatment of epilepsy. Experimental models of chemoconvulsant-induced status epilepticus remain the models of choice to discover potential antiepileptogenic drugs, but doubts remain as to the extent to which they model human pathophysiology. The aim of the present study was to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Epilepsy research and treatment
Share to Memory and Neural Mechanisms
Share to Neuroscience and Neuropharmacology Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 33070315
DOI: 10.1111/epi.16714

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

High concordance between hippocampal transcriptome of the mouse intra‐amygdala kainic acid model and human temporal lobe epilepsyPMID 33070315Read ↗

High concordance between hippocampal transcriptome of the intraamygdala kainic acid model and human temporal lobe epilepsySemantic proximity Read ↗

Transcriptome profiling implicates a role for Wnt signaling during epileptogenesis in a mouse model of temporal lobe epilepsySemantic proximity Read ↗

Spontaneous recurrent seizures in an intra-amygdala kainate microinjection model of temporal lobe epilepsy are differentially sensitive to antiseizure drugsSemantic proximity Read ↗

Inhibition of Endocannabinoid Degradation in Astrocytes Reprograms Glial Reactivity and Prevents Seizure SequelaeSemantic proximity Read ↗

EPILEPTOGENESIS INHIBITS THE CIRCADIAN CLOCK AND RESHAPES THE DIURNAL TRANSCRIPTOMIC RHYTHMICITY IN THE MOUSE HIPPOCAMPUSSemantic proximity Read ↗

Systematic review and meta-analysis of differentially expressed miRNAs in experimental and human temporal lobe epilepsy.Semantic proximity Read ↗

Single-Nucleus Transcriptomics Reveals Cell Type-Specific Remodeling and Epilepsy-Associated MicrogliaSemantic proximity Read ↗

Transcriptome Analysis of the Hippocampal CA1 Pyramidal Cell Region after Kainic Acid-Induced Status Epilepticus in Juvenile RatsSemantic proximity Read ↗

A systems level, functional genomics analysis of chronic epilepsy.Semantic proximity Read ↗

Neuronal and glial DNA methylation and gene expression changes in early epileptogenesis.Semantic proximity Read ↗

Expression Pattern of Epilepsy Associated Genes as a Common Pathological Signature in PTE and SE models and possible therapeutics via an in-silico approachSemantic proximity Read ↗

Proteomic Profiling of the Hippocampus of Rats Subjected to the Pilocarpine Model of EpilepsySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.