Article

Antibody-Based Targeting of the SPP1-CD44 Axis in Pediatric High-Grade Glioma through Single-Cell and Structural Bioinformatics

2025-05-07

Abstract excerpt

Pediatric high-grade glioma (pHGG) is a highly aggressive brain tumor characterized by transcriptional plasticity and an immunosuppressive microenvironment. Single-cell RNA-seq analysis revealed diverse malignant and immune cell populations, with tumor-associated macrophages (TAMs) emerging as the primary source of SPP1 (osteopontin), a glycoprotein that suppresses T cell activation through CD44 binding. Cell-cell...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: eaaf04bc-bb0b-50b0-b801-0a53594afe95
DOI: 10.1101/2025.05.01.651763

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Antibody-Based Targeting of the SPP1-CD44 Axis in Pediatric High-Grade Glioma through Single-Cell and Structural BioinformaticsDOI 10.1101/2025.05.01.651763Read

Single-cell spatial analysis of pediatric high-grade glioma reveals a novel population of SPP1 <sup>+</sup> /GPNMB <sup>+</sup> myeloid cells with immunosuppressive and tumor-promoting capabilitiesSemantic proximity Read

Multi-pronged analysis of pediatric low-grade glioma reveals a unique tumor microenvironment associated with BRAF alterationsSemantic proximity Read

SPP1 as a Prognostic and Immunotherapeutic Biomarker in Gliomas and Other Cancer Types: A Pan-Cancer StudySemantic proximity Read

Single-Cell Transcriptomic Analysis Revealed a Critical Role of SPP1/CD44-Mediated Crosstalk Between Macrophages and Cancer Cells in GliomaSemantic proximity Read

Dissecting the immune landscape in pediatric high-grade glioma reveals cell state changes under therapeutic pressureSemantic proximity Read

Defining the extracellular matrix for targeted immunotherapy in adult and pediatric brain cancerSemantic proximity Read

Integrated Multi-Omics Identifies Lineage-Dependent Myeloid Cells Recruitment and the APP-CD74 Axis as an Immunoregulatory Target in Pediatric High-Grade GliomaSemantic proximity Read

RUNX1/CD44 axis regulates the proliferation, migration, and immunotherapy of gliomas: A single-cell sequencing analysis.Semantic proximity Read

Single-cell RNA Sequencing Reveals Immunosuppressive Myeloid Cell Diversity and Restricted Cytotoxic Effector Cell Trafficking and Activation During Malignant Progression in GliomaSemantic proximity Read

Integrated Proteogenomic Characterization across Major Histological Types of Pediatric Brain Cancer.Semantic proximity Read

7aaRGD - a novel SPP1/integrin signaling-blocking peptide reverses immunosuppression and improves anti-PD-1 immunotherapy outcomes in experimental gliomasSemantic proximity Read

Immunosuppressive tumor microenvironment of osteosarcomaSemantic proximity Read