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Article

RUNX1/CD44 axis regulates the proliferation, migration, and immunotherapy of gliomas: A single-cell sequencing analysis.

Frontiers in immunology - 1 Jan 2023

Zhang Hao, Cao Hui, Luo Hong, Zhang Nan, Wang Zeyu, Dai Ziyu, Wu Wantao, Liu Guodong, Xie Zongyi, Cheng Quan, Cheng Yuan

Abstract excerpt

Background: Glioma is one of the most common, primary, and lethal adult brain tumors because of its extreme aggressiveness and poor prognosis. Several recent studies relevant to the immune function of CD44, a transmembrane glycoprotein as a significant hyaluronic acid receptor, have achieved great success, revealing the critical role of CD44 in immune infiltration in gliomas. The overexpression of CD44 has been...

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Identifiers

PMID: 36776876
DOI: 10.3389/fimmu.2023.1086280
PMCID: PMC9909339

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