Article

Immunosuppressive tumor microenvironment of osteosarcoma

2023-11-03

Abstract excerpt

Osteosarcoma is the most common malignant bone tumor in children, characterized by a high degree of genomic instability, resulting in copy-number alterations and genomic rearrangements without disease-defining recurrent mutations. Clinical trials based on molecular characterization have failed to find new effective therapies or improve outcomes over the last 40 years. To better understand the immune microenvironme...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 23153ab3-596c-5f2e-ac14-7dfec06b42eb
DOI: 10.1101/2023.11.01.565008

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Immunosuppressive tumor microenvironment of osteosarcomaDOI 10.1101/2023.11.01.565008Read

Spatial profiling identifies regionally distinct microenvironments and targetable immunosuppressive mechanisms in pediatric osteosarcoma pulmonary metastasesSemantic proximity Read

Single-cell RNA landscape of intratumoral heterogeneity and immunosuppressive microenvironment in advanced osteosarcomaSemantic proximity Read

Single-cell RNA sequencing reveals the cellular and molecular heterogeneity of treatment-naïve primary osteosarcoma in dogsSemantic proximity Read

Integrated single-cell analysis reveals heterogeneity and therapeutic insights in osteosarcomaSemantic proximity Read

Genomics and the Immune Landscape of Osteosarcoma.Semantic proximity Read

Comprehensive investigation of tumor immune microenvironment and prognostic biomarkers in osteosarcoma through integrated bulk and single-cell transcriptomic analysisSemantic proximity Read

Single-cell RNA landscape of the intratumoral heterogeneity and expression of angiogenesis-related genes in osteosarcomaSemantic proximity Read

Single-cell RNA sequencing reveals the immune microenvironment landscape of osteosarcoma before and after chemotherapySemantic proximity Read

Classification of Osteosarcoma Based on Immunogenomic ProfilingSemantic proximity Read

Comprehensive analysis of potential cellular communication networks in advanced osteosarcoma using single-cell RNA sequencing dataSemantic proximity Read

Osteosarcoma: Integrating Epidemiological Insights, Genomic Advances, Environmental Determinants, and Novel Therapeutic Strategies in Contemporary Oncological PracticeSemantic proximity Read

Identification and Validation of a Novel Immune-related Five-lncRNA Signature for OsteosarcomaSemantic proximity Read