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Defining the extracellular matrix for targeted immunotherapy in adult and pediatric brain cancer

14 Jun 2025

Abstract excerpt

High-grade gliomas (HGGs), including glioblastoma (GBM) and pediatric diffuse midline gliomas (DMGs), remain highly fatal despite therapeutic advances. The tumor microenvironment (TME), particularly the extracellular matrix (ECM), plays a crucial role in tumor progression, immune exclusion, and drug resistance. We performed a comprehensive proteomic, transcriptomic, and pathological characterization of the ECM in...

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PMID: 40517137
DOI: 10.1038/s41698-025-00956-z

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