Article

Transient Polycomb activity represses developmental genes in growing oocytes

2022-09-19

Abstract excerpt

<h4>Background</h4> Non-genetic disease inheritance and offspring phenotype is substantially influenced by germline epigenetic programming, including genomic imprinting. Loss of Polycomb Repressive Complex 2 (PRC2) function in oocytes causes non-genetically inherited effects on offspring, including embryonic growth restriction followed by post-natal offspring overgrowth. While PRC2 dependent non-canonical imprint...

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Literature Corpus work: eaa2c7d3-babc-5a61-8448-20561e827435
DOI: 10.1101/2022.09.18.508436

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