Article

Loss of EED in the oocyte causes initial fetal growth restriction followed by placental hyperplasia and offspring overgrowth

2022-08-11

Abstract excerpt

Germline epigenetic programming, including genomic imprinting, substantially influences offspring development. Polycomb Repressive Complex 2 (PRC2) plays an important role in Histone 3 Lysine 27 trimethylation (H3K27me3)-dependent imprinting, loss of which leads to placental hyperplasia in mammalian offspring generated by somatic cell nuclear transfer (SCNT). In this study, we show that offspring from mouse oocyte...

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Literature Corpus work: 47c5a106-01fb-581a-be54-6452308e7c1d
DOI: 10.1101/2022.08.08.503175

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Loss of EED in the oocyte causes initial fetal growth restriction followed by placental hyperplasia and offspring overgrowthDOI 10.1101/2022.08.08.503175Read

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