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Epigenetic programming in the ovarian reserve

7 Jul 2023

Abstract excerpt

The ovarian reserve defines female reproductive lifespan, which in humans spans decades. The ovarian reserve consists of oocytes residing in primordial follicles arrested in meiotic prophase I and is maintained independent of DNA replication and cell proliferation, thereby lacking stem cell-based maintenance. Largely unknown is how cellular states of the ovarian reserve are established and maintained for decades....

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PMID: 37417392
DOI: 10.1002/bies.202300069

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