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Germ line–inherited H3K27me3 restricts enhancer function during maternal-to-zygotic transition

14 Jul 2017

Abstract excerpt

oocytes transmit the repressive histone mark H3K27me3 to their offspring. Maternal contribution of the histone methyltransferase Enhancer of zeste, the enzymatic component of Polycomb repressive complex 2, is required for active propagation of H3K27me3 during early embryogenesis. H3K27me3 in the early embryo prevents aberrant accumulation of the active histone mark H3K27ac at regulatory regions and precocious...

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PMID: 28706074
DOI: 10.1126/science.aam5339

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