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Article

Transient Polycomb activity represses developmental genes in growing oocytes

1 Dec 2022

Abstract excerpt

BACKGROUND: Non-genetic disease inheritance and offspring phenotype are substantially influenced by germline epigenetic programming, including genomic imprinting. Loss of Polycomb Repressive Complex 2 (PRC2) function in oocytes causes non-genetically inherited effects on offspring, including embryonic growth restriction followed by post-natal offspring overgrowth. While PRC2-dependent non-canonical imprinting is...

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PMID: 36544159
DOI: 10.1186/s13148-022-01400-w

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