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PRC1-mediated epigenetic programming is required to generate the ovarian reserve

10 Aug 2022

Abstract excerpt

The ovarian reserve defines the female reproductive lifespan, which in humans spans decades due to robust maintenance of meiotic arrest in oocytes residing in primordial follicles. Epigenetic reprogramming, including DNA demethylation, accompanies meiotic entry, but the chromatin changes that underpin the generation and preservation of ovarian reserves are poorly defined. We report that the Polycomb Repressive...

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PMID: 35948547
DOI: 10.1038/s41467-022-31759-6

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