Article

Depressive-like behaviors induced by somatostatin-positive GABA neuron silencing are rescued by alpha 5 GABA-A receptor potentiation

2020-10-06

Abstract excerpt

<h4>Introduction</h4> Deficits in somatostatin-positive gamma-aminobutyric acid interneurons (“SST+ cells”) are associated with major depressive disorder (MDD) and a causal link between SST+ cell dysfunction and depressive-like deficits has been proposed, based on rodent studies showing that chronic stress induces a low SST+ GABA cellular phenotype across corticolimbic brain regions, that lowering Sst , SST+ cel...

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Literature Corpus work: ea8f74b4-15ab-5f01-9ff2-0f9c935315be
DOI: 10.1101/2020.10.05.326306

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