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Article

The GABAergic deficit hypothesis of major depressive disorder.

Molecular psychiatry - 1 Apr 2011

Luscher B, Shen Q, Sahir N

Abstract excerpt

Increasing evidence points to an association between major depressive disorders (MDDs) and diverse types of GABAergic deficits. In this review, we summarize clinical and preclinical evidence supporting a central and causal role of GABAergic deficits in the etiology of depressive disorders. Studies of depressed patients indicate that MDDs are accompanied by reduced brain concentration of the inhibitory...

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Identifiers

PMID: 21079608
DOI: 10.1038/mp.2010.120
PMCID: PMC3412149

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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