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Article

mGluR5 in ECCCK to BLA Circuit Modulates Depressive-Like Phenotypes through CCK Signaling.

Advanced science (Weinheim, Baden-Wurttemberg, Germany) - 1 Aug 2026

Asim Muhammad, Wang Huajie, Qianqian Gao, Waris Abdul, He Jufang

Abstract excerpt

Dysregulation of metabotropic glutamate receptor 5 (mGluR5) and cholecystokinin (CCK) signaling has been implicated in major depressive disorder (MDD), but the underlying circuit mechanisms remain unclear. Here, we define how mGluR5 regulates depressive-like behaviors through CCK signaling in the entorhinal cortex (EC) to basolateral amygdala (BLA) pathway. Anatomical tracing and optogenetics show that...

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Identifiers

PMID: 42102389
DOI: 10.1002/advs.202523115
PMCID: PMC13335908

Genes

CCK

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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