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Transcriptome signatures of the medial prefrontal cortex underlying GABAergic control of resilience to chronic stress exposure

15 Nov 2024

Abstract excerpt

Analyses of postmortem human brains and preclinical studies of rodents have identified somatostatin (SST)-positive, dendrite-targeting GABAergic interneurons as key elements that regulate the vulnerability to stress-related psychiatric disorders. Conversely, genetically induced disinhibition of SST neurons (induced by Cre-mediated deletion of the γ2 GABA A receptor subunit gene selectively from SST neurons,...

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PMID: 39550415
DOI: 10.1038/s41380-024-02832-x

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