Article

Chronic stress induces co-ordinated cortical microcircuit cell type transcriptomic changes consistent with altered information processing

2020-08-18

Abstract excerpt

<h4>ABSTRACT</h4> Major depressive disorder (MDD) is associated with altered GABAergic and glutamatergic signalling, suggesting altered excitation-inhibition balance (EIB) in cortical mood- and cognition-regulating brain regions. Information processing in cortical microcircuits involves regulation of pyramidal (PYR) cells by Somatostatin-(SST), Parvalbumin-(PV), and Vasoactive intestinal peptide-(VIP) expressing...

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Literature Corpus work: 150a9fb1-5ded-5e5c-89dd-fd57fbe31877
DOI: 10.1101/2020.08.18.249995

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