Article

Porcine pancreatic ductal epithelial cells transformed with KRAS G12D and SV40T are tumorigenic

2021-03-05

Abstract excerpt

We describe our initial studies in the development of an orthotopic, genetically-defined, large animal model of pancreatic cancer. Primary pancreatic epithelial cells were isolated from pancreatic duct of domestic pigs. A transformed cell line was generated from these primary cells with oncogenic KRAS and SV40T. The transformed cell lines outperformed the primary and SV40T immortalized cells in terms of proliferat...

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Literature Corpus work: ea8ae12e-666b-555a-b798-09646fb67a6f
DOI: 10.21203/rs.3.rs-268379/v1

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