Article

KRAS <sup>G12D</sup> and TP53 <sup>R167H</sup> Cooperate to Induce Pancreatic Ductal Adenocarcinoma in <i>Sus Scrofa</i> Pigs

2018-06-28

Abstract excerpt

Although survival has improved in recent years, the prognosis of patients with advanced pancreatic ductal adenocarcinoma (PDAC) remains poor. Despite substantial differences in anatomy, physiology, genetics, and metabolism, the overwhelming majority of preclinical testing relies on transgenic mice. Hence, while mice have allowed for tremendous advances in cancer biology, they have been a poor predictor of drug per...

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Literature Corpus work: 9c0a8df4-8cee-56ed-9bf2-fe9afba11ba8
DOI: 10.1101/358416

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