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Article

Organoid-based ex vivo reconstitution of Kras-driven pancreatic ductal carcinogenesis

20 Jun 2019

Abstract excerpt

The organoid culture technique has been recently applied to modeling carcinogenesis in several organs. To further explore its potential and gain novel insights into tumorigenesis, we here investigated whether pancreatic ductal adenocarcinoma (PDA) could be generated as subcutaneous tumors in immunocompromised nude mice, by genetic engineering of normal organoids. As expected, acute induction of KrasG12Din vitro...

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PMID: 31233118
DOI: 10.1093/carcin/bgz122

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