Article
Viable pigs with a conditionally-activated oncogenic KRAS mutation.
Transgenic research - 1 Jun 2015
Li Shun, Edlinger Marlene, Saalfrank Anja, Flisikowski Krzysztof, Tschukes Alexander, Kurome Mayuko, Zakhartchenko Valeri, Kessler Barbara, Saur Dieter, Kind Alexander, Wolf Eckhard, Schnieke Angelika, Flisikowska Tatiana
Abstract excerpt
Oncogenic mutations of KRAS play a major role in human carcinogenesis. Here we describe viable gene-targeted pigs carrying a latent KRAS (G12D) mutant allele that can be activated by Cre recombination. These have been produced as part of a program to model human cancers in pigs by replicating genetic lesions known to initiate and drive human disease. Cre-activated KRAS (G12D) animals add to a growing set of...
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