Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A human cancer xenograft model utilizing normal pancreatic duct epithelial cells conditionally transformed with defined oncogenes.

Carcinogenesis - 1 Aug 2014

Inagawa Yuki, Yamada Kenji, Yugawa Takashi, Ohno Shin-ichi, Hiraoka Nobuyoshi, Esaki Minoru, Shibata Tatsuhiro, Aoki Kazunori, Saya Hideyuki, Kiyono Tohru

Abstract excerpt

Pancreatic ductal adenocarcinomas (PDACs) are considered to arise through neoplastic transformation of human pancreatic duct epithelial cells (HPDECs). In order to evaluate the biological significance of genetic and epigenetic alterations in PDACs, we isolated primary HPDECs and established an in vitro carcinogenesis model. Firstly, lentivirus-mediated transduction of KRAS(G12V), MYC and human papillomavirus 16...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carcinoma, Pancreatic Ductal
Share to Cell Culture Techniques

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cyclin D1

Share to Cyclin-Dependent Kinase 4

Share to Immunoenzyme Techniques

Share to Pancreatic Ducts

Share to Telomerase

Share to Xenograft Model Antitumor Assays

Source

Identifiers

PMID: 24858378
DOI: 10.1093/carcin/bgu112

Genes

KRAS
MYC
CDK4
TERT

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A human cancer xenograft model utilizing normal pancreatic duct epithelial cells conditionally transformed with defined oncogenes.PMID 24858378Read ↗

Organoid-based ex vivo reconstitution of Kras-driven pancreatic ductal carcinogenesisSemantic proximity Read ↗

Modeling pancreatic cancer in mice for experimental therapeutics.Semantic proximity Read ↗

Molecular Pathogenesis of Pancreatic Cancer: Advances and ChallengesSemantic proximity Read ↗

Reconstituting development of pancreatic intraepithelial neoplasia from primary human pancreas duct cells.Semantic proximity Read ↗

Genetically engineered mouse models of pancreatic adenocarcinomaSemantic proximity Read ↗

Novel Pancreatic Cancer Cell Lines Derived from Genetically Engineered Mouse Models of Spontaneous Pancreatic Adenocarcinoma: Applications in Diagnosis and TherapySemantic proximity Read ↗

Deciphering the mechanisms of tumorigenesis in human pancreatic ductal epithelial cells.Semantic proximity Read ↗

Carcinogenesis of Pancreatic Ductal Adenocarcinoma.Semantic proximity Read ↗

In vitro Modeling of Human Pancreatic Duct Epithelial Cell Transformation Defines Gene Expression Changes Induced by K- ras Oncogenic Activation in Pancreatic CarcinogenesisSemantic proximity Read ↗

Mouse models of pancreatic cancerSemantic proximity Read ↗

Oncogenic Kras <sup>G12D</sup> specific non-covalent inhibitor reprograms tumor microenvironment to prevent and reverse early pre-neoplastic pancreatic lesions and in combination with immunotherapy regresses advanced PDAC in a CD8 <sup>+</sup> T cells dependent mannerSemantic proximity Read ↗

Selective impact of CDK4/6 suppression on patient-derived models of pancreatic cancerSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.