Article
KRASG12D and TP53R167H Cooperate to Induce Pancreatic Ductal Adenocarcinoma in Sus scrofa Pigs.
Scientific reports - 22 Aug 2018
Principe Daniel R, Overgaard Nana Haahr, Park Alex J, Diaz Andrew M, Torres Carolina, McKinney Ronald, Dorman Matthew J, Castellanos Karla, Schwind Regina, Dawson David W, Rana Ajay, Maker Ajay, Munshi Hidayatullah G, Rund Lauretta A, Grippo Paul J, Schook Lawrence B
Abstract excerpt
Although survival has improved in recent years, the prognosis of patients with advanced pancreatic ductal adenocarcinoma (PDAC) remains poor. Despite substantial differences in anatomy, physiology, genetics, and metabolism, the overwhelming majority of preclinical testing relies on transgenic mice. Hence, while mice have allowed for tremendous advances in cancer biology, they have been a poor predictor of drug...
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