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Induction of pancreatic neoplasia in the KRAS / TP53 Oncopig

29 Dec 2022

Abstract excerpt

The 5-year survival of pancreatic cancer (PC) remains low. Murine models may not adequately mimic human PC and can be too small for medical device development. A large-animal PC model could address these issues. We induced and characterized pancreatic tumors in Oncopigs (transgenic swine containing KRASG12D and TP53R167H). The oncopigs underwent injection of adenovirus expressing Cre recombinase (AdCre) into one...

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PMID: 36579622
DOI: 10.1242/dmm.049699

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