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Article

A Genetic Porcine Model of Cancer.

PloS one - 1 Jan 2015

Schook Lawrence B, Collares Tiago V, Hu Wenping, Liang Ying, Rodrigues Fernanda M, Rund Laurie A, Schachtschneider Kyle M, Seixas Fabiana K, Singh Kuldeep, Wells Kevin D, Walters Eric M, Prather Randall S, Counter Christopher M

Abstract excerpt

The large size of the pig and its similarity in anatomy, physiology, metabolism, and genetics to humans make it an ideal platform to develop a genetically defined, large animal model of cancer. To this end, we created a transgenic "oncopig" line encoding Cre recombinase inducible porcine transgenes encoding KRASG12D and TP53R167H, which represent a commonly mutated oncogene and tumor suppressor in human cancers,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26132737
DOI: 10.1371/journal.pone.0128864
PMCID: PMC4488487

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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