Article

Porcine pancreatic ductal epithelial cells transformed with KRAS <sup>G12D</sup> and SV40T are tumorigenic

2021-01-17

Abstract excerpt

We describe our initial studies in the development of an orthotopic, genetically-defined, large animal model of pancreatic cancer. Primary pancreatic epithelial cells were isolated from pancreatic duct of domestic pigs. A transformed cell line was generated from these primary cells with oncogenic KRAS and SV40T. The transformed cell lines outperformed the primary and SV40T immortalized cells in terms of proliferat...

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Literature Corpus work: 315ebf2b-7d95-5a68-a825-2c748008c4a1
DOI: 10.1101/2021.01.15.425792

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