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Article

Clinical, molecular and genetic validation of a murine orthotopic xenograft model of pancreatic adenocarcinoma using fresh human specimens.

PloS one - 1 Jan 2013

Walters Dustin M, Stokes Jayme B, Adair Sara J, Stelow Edward B, Borgman Cheryl A, Lowrey Bryce T, Xin Wenjun, Blais Edik M, Lee Jae K, Papin Jason A, Parsons J Thomas, Bauer Todd W

Abstract excerpt

BACKGROUND: Relevant preclinical models that recapitulate the key features of human pancreatic ductal adenocarcinoma (PDAC) are needed in order to provide biologically tractable models to probe disease progression and therapeutic responses and ultimately improve patient outcomes for this disease. Here, we describe the establishment and clinical, pathological, molecular and genetic validation of a murine,...

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Share to Carcinoma, Pancreatic Ductal
Share to Mice, Inbred NOD

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mice, SCID

Share to Neoplasm Transplantation

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Source

Open in PubMed Open full text

Identifiers

PMID: 24204737
DOI: 10.1371/journal.pone.0077065
PMCID: PMC3799939

Genes

EGFR
KRAS
SMAD4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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