Article

PDE10A Inhibition Reduces NLRP3 Activation and Pyroptosis in Sepsis and Nerve Injury

2025-03-17

Abstract excerpt

<h4> Abstract </h4> Cell death and inflammation are key innate immune responses, but excessive activation can cause tissue damage. The NLRP3 inflammasome is a promising target for reducing inflammation and promoting recovery. Immunometabolism regulates NLRP3 responses in neurological and inflammatory diseases through cyclic nucleotide signaling. Targeting phosphodiesterases (PDEs), which hydrolyze cAMP and cGMP,...

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Literature Corpus work: ea7b89ae-ca26-5370-b89f-87908e14837e
DOI: 10.1101/2025.03.17.643692

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