Article

P2RY6 activation aggravates NLRP3-dependent microglial pyroptosis via down-regulation of the PI3K/AKT pathway in a mouse model of intracerebral hemorrhage

2022-11-04

Abstract excerpt

<title>Abstract</title><p>Background Pro-inflammatory signals generated after intracerebral hemorrhage (ICH) trigger a form of regulated cell death known as pyroptosis in microglia. Although the p2Y purinoceptor 6 (P2RY6) plays a significant role in control of inflammatory reactions in central nervous system diseases, its roles in the development of neuroinflammation and microglial pyroptosis following ICH remain...

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Literature Corpus work: 33d32400-2b70-54a9-b9cf-c09b57ace8bd
DOI: 10.21203/rs.3.rs-2206691/v1

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