Article

CGRPβ suppresses the pathogenesis of ulcerative colitis via the immunoproteasome

2024-12-23

Abstract excerpt

<title>Abstract</title> <p>Various factors have been implicated in the pathogenesis of ulcerative colitis (UC), with immune system failure being the most important one. Calcitonin gene-related peptide (CGRP), a neuropeptide with two isoforms, CGRPα and CGRPβ, has been reported to regulate the immune system. In this study, we investigated the role of CGRP isoforms in UC pathogenesis. We induced UC-like symptoms in...

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Literature Corpus work: 847f0e1f-40c4-5893-b9a2-cf58d76e7d28
DOI: 10.21203/rs.3.rs-5073786/v1

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