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Article

Pharmacologic Targeting of PDIA1 Inhibits NLRP3 Inflammasome Assembly and Activation

2023-08-22

Abstract excerpt

<h4>SUMMARY</h4> The NLRP3 inflammasome is a cytosolic protein complex that regulates innate immune signaling in response to diverse pathogenic insults through the proteolytic processing and secretion of pro-inflammatory cytokines such as IL-1β. Hyperactivation of NLRP3 inflammasome signaling is implicated in the onset and pathogenesis of numerous diseases, motivating the discovery of new strategies to suppress N...

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Literature Corpus work
1a6ca940-c85e-55af-a92a-889596b34081
DOI
10.1101/2023.08.21.554183
Open publication

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Pharmacologic Targeting of PDIA1 Inhibits NLRP3 Inflammasome Assembly and ActivationDOI 10.1101/2023.08.21.554183
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