Article

Glibenclamide Directly Prevents Neuroinflammation by Targeting SUR1-TRPM4-Mediated NLRP3 Inflammasome Activation in Microglia

2021-11-02

Abstract excerpt

<h4>Background: </h4> Glibenclamide (GLB) reduces brain edema and improves neurological outcome in animal experiments and preliminary clinical studies. Recent studies also suggested a strong anti-inflammatory effect of GLB, via inhibiting Nucleotide-binding oligomerization domain-like receptor containing pyrin domain 3 (NLRP3) inflammasome activation. However, it remains unknown whether the anti-inflammatory effec...

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Literature Corpus work: 472098da-1172-5df9-9815-fcce681122e4
DOI: 10.21203/rs.3.rs-980762/v1

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