Article

GSDMD-dependent platelet pyroptosis exacerbates NET formation and inflammation in severe sepsis

2022-03-21

Abstract excerpt

<title>Abstract</title> <p>Dysregulated inflammation is closely associated with increased mortality in sepsis. Platelets have emerged as key inflammatory cells implicated in the pathology of sepsis, including the development of thrombosis, thrombocytopenia, and neutrophil extracellular traps (NETs). Platelet’s contributions to rapid clinical deterioration and dysregulated inflammation in sepsis have not been defi...

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Literature Corpus work: bfc8d812-ffe8-5ff4-8650-0ff18c737418
DOI: 10.21203/rs.3.rs-1462784/v1

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