Article

Disease-associated loci share properties with response eQTLs under common environmental exposures

2025-05-14

Abstract excerpt

<title>Abstract</title> <p>Many of the genetic loci associated with disease are expected to have context-dependent regulatory effects that are underrepresented in the transcriptomes of healthy, steady-state adult tissues. To understand gene regulation across diverse environmental conditions and cellular contexts, we treated a broad array of human cell types with three environmental exposures in vitro. With single...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: ea7897ed-9668-5955-a3b4-5b14699ee678
DOI: 10.21203/rs.3.rs-6561377/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Disease-associated loci share properties with response eQTLs under common environmental exposuresDOI 10.21203/rs.3.rs-6561377/v1Read

Disease-associated loci share properties with response eQTLs under common environmental exposuresSemantic proximity Read

High-throughput allele-specific expression across 250 environmental conditions.Semantic proximity Read

Beyond the baseline: mapping the context-specific regulatory landscape of disease.Semantic proximity Read

An integrated approach to identify environmental modulators of genetic risk factors for complex traits.Semantic proximity Read

Large-scale cis- and trans-eQTL analyses identify thousands of genetic loci and polygenic scores that regulate blood gene expression.Semantic proximity Read

An integrated approach to identify environmental modulators of genetic risk factors for complex traitsSemantic proximity Read

<i>Trans</i> -eQTLs reveal the architecture of human gene regulatory networksSemantic proximity Read

Diverse environmental perturbations reveal the evolution and context-dependency of genetic effects on gene expression levelsSemantic proximity Read

Interactions between genetic variation and cellular environment in skeletal muscle gene expression.Semantic proximity Read

Where Are the Disease-Associated eQTLs?Semantic proximity Read

Interactions between genetic variation and cellular environment in skeletal muscle gene expressionSemantic proximity Read

Scalable context-dependent single-cell eQTL mapping reveals disease-relevant regulatory variation beyond static modelsSemantic proximity Read