Article

<i>Trans</i> -eQTLs reveal the architecture of human gene regulatory networks

2026-02-05

Abstract excerpt

Many non-coding variants influence complex traits and diseases through gene regulation, yet the mechanisms linking these variants to downstream biology remain poorly understood. Here, we present eQTLGen Phase 2 , a comprehensive genome-wide analysis of gene expression quantitative trait loci (eQTLs) in 43,301 blood samples from 52 datasets. Beyond local cis -effects, this sample size enabled the first systematic...

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Literature Corpus work: da1e5575-776a-5ba9-90ad-441258ae4186
DOI: 10.64898/2026.02.04.26343575

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