Interactions between genetic variation and cellular environment in skeletal muscle gene expression.

doi:10.1371/journal.pone.0195788

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Article

Interactions between genetic variation and cellular environment in skeletal muscle gene expression.

PloS one - 1 Jan 2018

Taylor D Leland, Knowles David A, Scott Laura J, Ramirez Andrea H, Casale Francesco Paolo, Wolford Brooke N, Guan Li, Varshney Arushi, Albanus Ricardo D'Oliveira, Parker Stephen C J, Narisu Narisu, Chines Peter S, Erdos Michael R, Welch Ryan P, Kinnunen Leena, Saramies Jouko, Sundvall Jouko, Lakka Timo A, Laakso Markku, Tuomilehto Jaakko, Koistinen Heikki A, Stegle Oliver, Boehnke Michael, Birney Ewan, Collins Francis S

Abstract excerpt

From whole organisms to individual cells, responses to environmental conditions are influenced by genetic makeup, where the effect of genetic variation on a trait depends on the environmental context. RNA-sequencing quantifies gene expression as a molecular trait, and is capable of capturing both genetic and environmental effects. In this study, we explore opportunities of using allele-specific expression (ASE)...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 29659628
DOI: 10.1371/journal.pone.0195788
PMCID: PMC5901994

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